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Two studies comparing the efficacy of nystatin pastilles to the placebo in treating denture stomatitis were analyzed by meta-analysis. The clinical and mycological cure rates associated with nystatin and the control treatments are summarized in Table 2. A third reviewer (HH or ZMY) was invited to make an assessment if the two review authors could not reach a consensus. The Kappa coefficient was used to calculate inter-rater agreement with regard to study inclusion and quality assessment. The following assessment criteria were used to assess the quality of the studies: 1) random sequence generation (if the study did not use this method, it was considered to have a selection bias), 2) allocation concealment (selection bias), 3) blinding of participants and personnel (performance bias), 4) blinding of outcome assessment (detection bias), 5) incomplete outcome data (attrition bias), 6) selective reporting (reporting bias), and 7) other biases. The quality of the included studies was assessed using the Cochrane Handbook for Systematic Review of Interventions and the Rev Man 5.2.0 software. All the relevant data of each included study, including author, year of publication, region, risk factors, characteristics of the patients, detailed interventions, outcomes, and adverse effects, were extracted and summarized in a table format. The two review authors (XL, CZ) were independently responsible for scanning titles and abstracts, selecting studies, reading full reports, extracting data, and assessing the quality of studies these steps were performed in duplicate by each of these authors. The aim of this study was to summarize and assess the efficacy, different treatment protocols (formulation, dosage, and duration), and safety of nystatin in different patient populations with oral candidiasis by a meta-analysis and systematic review. 5, 21– 23 Up to now, there is no consensus on the formulation, dosage, or treatment duration of nystatin in the treatment of oral candidiasis. 18, 20 Treatment duration can vary from 1 or 2 to 4 weeks. 16– 19 The common recommended dose for topical use of nystatin is 200,000–600,000 IU qid for children and adults, and 100,000–200,000 IU qid for newborns and infants. Further, nystatin also plays an important role in the prophylaxis of oral and systemic candidiasis in full-term and premature newborns, infants, and immunocompromised patients (eg, AIDS patients, cancer patients, and organ transplant recipients), as it is associated with a low incidence of drug interactions and acceptable costs, especially in developing countries. 5 Therefore, the topical use of nystatin is considered the most common route of administration in dentistry, as systemic exposure is minimal. 11– 15 Nystatin is not absorbed from gastrointestinal tract when orally administered. Nystatin is a membrane-active polyene macrolide produced by Streptomyces noursei strains and is available in various forms, such as oral suspension, topical cream, and oral pastille. 7, 8 Topical antifungal agents, such as nystatin, amphotericin B, miconazole, and clotrimazole, are recommended typically as the first-line treatment for uncomplicated cases of oral candidiasis. 3, 6 However, numerous drug interactions and decreased susceptibility of species other than Candida albicans toward azoles limit the application of systemic antifungal agents. 3 Systemic antifungal agents, including triazoles, fluconazole, and itraconazole, are appropriate for patients who do not respond to or are intolerant to topical treatment and those at high risk of developing systemic infections. Various topical and systemic agents are currently available for the treatment of oral candidiasis. 3– 5 Elimination of the predisposing factors is an important strategy in treating oral candidiasis. 1, 2 It has been associated with multiple host risk factors, including impaired salivary gland function, denture wearing, oral mucosa disruption, drug use (long-term administration of broad-spectrum antibiotics, corticosteroids, antidepressants, antineoplastic, drugs, and immunosuppressant), age (common in neonates and the elderly), endocrine alterations (diabetes mellitus, pregnancy, renal failure, and hyperthyroidism), dietary factors (high-carbohydrate diet and iron-deficiency anemia), cancer, and HIV infection. Oral candidiasis, which is the most common human fungal infection, is characterized by an overgrowth of Candida species in the superficial epithelium of the oral mucosa. Symbols, abbreviations, or full names for units of length,Īrea, mass, pressure, and other types. You can find metric conversion tables for SI units, as wellĪs English units, currency, and other data. Any pressure value in pascals can be changed into a pressure in pounds per square inches using the following conversion factor: 1 psi 6,894. The unit is named after Blaise Pascal, the eminent French mathematician, physicist and philosopher.Ĭonversion calculator for all types of measurement units. The definition of a pascal is as follows: The SI prefix "kilo" represents a factor of Psf to kPa, or enter any two units below: Enter two units to convert From: Psi to Kilopascal Conversion Table Psi ġ5 psi = 15 × 6.8947572932 kPa = 103.You can do the reverse unit conversion from This is true of most countries, including the United States. The kilopascal is more prevalent in scientific contexts such as material science, engineering, and geophysics. Exceptions include certain countries that use either the imperial or United States customary systems of measurement, such as the United States, in which the unit of pound per square inch is more commonly used. In 1971, at the 14 th General Conference on Weights and Measures, the pascal was adopted as an SI derived unit of pressure.Ĭurrent use: The kilopascal is widely used worldwide in countries that have adopted SI. The kilopascal is simply a multiple of the pascal, as is common within SI. Conversion of 20 pounds per square inch to other pressure units. History/origin: The unit, pascal, is named after Blaise Pascal, a French mathematician and physicist. So, 20 pounds per square inch 20 × 0.06804596378 1.3609192756 atm. Kilopascalĭefinition: A kilopascal (symbol: kPa) is a multiple of the pascal (Pa), an SI (International System of Units) derived unit of pressure used to measure internal pressure, Young's modulus, stress, and ultimate tensile strength. Although the pascal is more widely used in scientific contexts, psi is more often used in everyday contexts, particularly in countries like the United States as well as others under the US customary or imperial systems of units. As such, the prototype pound at the time was known as the avoirdupois wool pound.Ĭurrent use: The psi is fairly widely used to measure numerous pressures, such as tire pressure, scuba tank pressure, natural gas pipeline pressure, among others. Psi (Pound Force Per Square Inch) Conversion: Psi is a pressure unit and equals to the force of one pound applied to one square inch. Convert blood pressure from mm Hg to kPa, convert blood pressure from kPa to mm Hg, Convert American psi to European kPal. 137895.14586 Pascal (Pa) Visit 20 Pascal to Psi Conversion Psi : Psi is the abbreviation of pound per square inch, and is widely used in British and American. The system is believed to have come into use in England around 1300 and was used in the international wool trade. The converter permits the user to convert blood pressue between mm Hg and kPa. It is based on the avoirdupois system, a system that uses weights in terms of the avoirdupois pound, which was standardized in 1959. 1 MPa 145.03773773 psi 1 psi 0.0068947573 MPa. P0 20 Pa, micropascal If you need to change the reference pressure. History/origin: Pound-force per square inch is a unit that originated in the imperial and US customary systems of units. 35939767 Pa Popular Pressure Unit Conversions bar to psi psi to bar kpa to psi psi. One psi is approximately 6,895 pascals (N/m 2). It is defined as the pressure that results when a force of one pound-force is applied to a one-square-inch area. Definition: A pound-force per square inch (symbol: psi) is an imperial and US customary unit of pressure based on avoirdupois units. Usually commercial software or games are produced for sale or to serve a commercial purpose. Even though, most trial software products are only time-limited some also have feature limitations. After that trial period (usually 15 to 90 days) the user can decide whether to buy the software or not. Trial software allows the user to evaluate the software for a limited amount of time. Demos are usually not time-limited (like Trial software) but the functionality is limited. In some cases, all the functionality is disabled until the license is purchased. Demoĭemo programs have a limited functionality for free, but charge for an advanced set of features or for the removal of advertisements from the program's interfaces. In some cases, ads may be show to the users. 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